Syntheses, electrochemistry and cytotoxicity of ferrocene-containing polyaspartamides as water‐soluble polymeric drug carrier/drug conjugates

2002 ◽  
Vol 186 (1) ◽  
pp. 123-128 ◽  
Author(s):  
J.C. Swarts
Keyword(s):  
Drug Carrier ◽  
Water Soluble ◽  
Polymeric Drug Carrier ◽  
Drug Conjugates ◽  
Polymeric Drug

scholarly journals Synthesis and Anchoring of Antineoplastic Ferrocene and Phthalocyanine Derivatives on Water-Soluble Polymeric Drug Carriers Derived from Lysine and Aspartic Acid

2008 ◽  
Vol 2008 ◽  
pp. 1-10 ◽  
Author(s):  
M. David Maree ◽  
Eberhard W. Neuse ◽  
Elizabeth Erasmus ◽  
Jannie C. Swarts
Keyword(s):  
Aspartic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Amide Bond ◽  
Drug Conjugates ◽  
Synthetic Strategy ◽  
Coupling Reagent ◽  
Polymeric Drug ◽  
Derivatives Of

The general synthetic strategy towards water-soluble biodegradable drug carriers and the properties that they must have are discussed. The syntheses of water-soluble biodegradable copolymers of lysine and aspartic acid as potential drug-delivering devices, having amine-functionalised side chains are then described. Covalent anchoring of carboxylic acid derivatives of the antineoplastic ferrocene and photodynamically active phthalocyanine moieties to the amine-containing drug carrier copolymers under mild coupling conditions has been achieved utilising the coupling reagent O-benzotriazolyl-N,N,N′,N′-tetramethyluronium hexafluorophosphate to promote formation of the biodegradable amide bond. Even though the parent antineoplastic ferrocene and phthalocyanine derivatives are themselves insoluble in water at pH < 7, the new carrier-drug conjugates that were obtained are well water-soluble.

Fractionation and Characterization of a Conjugate between a Polymeric Drug-Carrier and the Antitumor Drug Camptothecin

2002 ◽  
Vol 13 (6) ◽  
pp. 1253-1258 ◽  
Author(s):  
R. Mendichi ◽  
V. Rizzo ◽  
M. Gigli ◽  
A. Giacometti Schieroni
Keyword(s):  
Drug Carrier ◽  
Antitumor Drug ◽  
Polymeric Drug Carrier ◽  
Polymeric Drug

Investigation of poly(methyl acrylate) grafted chitosan as a polymeric drug carrier

2014 ◽  
Vol 71 (7) ◽  
pp. 1575-1590 ◽  
Author(s):  
Ahmed Jasim M. Al-Karawi ◽  
Zyad H. Jawad Al-Qaisi ◽  
Alaa H. Jawad Al-Qaisi ◽  
Faliah Hassan A. Al-Jeboori
Keyword(s):  
Methyl Acrylate ◽  
Drug Carrier ◽  
Polymeric Drug Carrier ◽  
Polymeric Drug

Development of new bio-based polyol ester from palm oil for potential polymeric drug carrier

2018 ◽  
Vol 37 (8) ◽  
pp. 3552-3560 ◽  
Author(s):  
Rida Tajau ◽  
Rosiah Rohani ◽  
Wan Nor Roslam Wan Isahak ◽  
Mek Zah Salleh ◽  
Zulkafli Ghazali
Keyword(s):  
Palm Oil ◽  
Drug Carrier ◽  
Polyol Ester ◽  
Polymeric Drug Carrier ◽  
Polymeric Drug

Nano-Sized Polymeric Drug Carrier Systems

2014 ◽  
pp. 81-141
Author(s):  
Cornelia Vasile ◽  
Manuela Nistor ◽  
Anca-Maria Cojocariu
Keyword(s):  
Drug Carrier ◽  
Polymeric Drug Carrier ◽  
Polymeric Drug ◽  
Carrier Systems ◽  
Drug Carrier Systems

scholarly journals Abstract No. 14: Treatment of HCC with an ultrasound sensitive polymeric drug carrier in a rat model

2011 ◽  
Vol 22 (3) ◽  
pp. S10
Author(s):  
S.B. White ◽  
M. Cochran ◽  
J. Eisenbrey ◽  
E. Furth ◽  
M. Wheatley ◽  
...  
Keyword(s):  
Rat Model ◽  
Drug Carrier ◽  
Polymeric Drug Carrier ◽  
Polymeric Drug

Poly(?-malic acid) : a new polymeric drug-carrier

1985 ◽  
Vol 13 (4) ◽  
Author(s):  
Christian Braud ◽  
Claude Bunel ◽  
Michel Vert
Keyword(s):  
Malic Acid ◽  
Drug Carrier ◽  
Polymeric Drug Carrier ◽  
Polymeric Drug
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